tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate

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Chemical Name:tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate
CAS No.:1443792-25-3
Molecular Formula:C₂₉H₃₃N₇O₃
Molecular Weight:527.626
Hs Code.:

Synonyms:tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate

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Chemical Property of tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate

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Technology Process of tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate

There total 7 articles about tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1443792-21-9
tert-butyl (S)-2-(4-(tert-butyl)benzamido)-3-(4-(5-cyanopyrimidin-2-yl)phenyl)propanoate

: 1443792-25-3
tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

Reference yield:

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 1443792-25-3
tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: HATU; triethylamine / N,N-dimethyl-formamide / 5 h

2: N-ethyl-N,N-diisopropylamine / 36 h

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

4: sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 1 h / 110 °C / Microwave irradiation

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 0.75 h / 80 °C / Inert atmosphere

6: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 3 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; potassium acetate; sodium hydrogencarbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 16874-12-7,87553-74-0
Tyr(tBu)

: 1443792-25-3
tert-butyl (S)-3-(4-(5-(2H-tetrazol-5-yl)pyrimidin-2-yl)phenyl)-2-(4-(tert-butyl)-benzamido)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: HATU; triethylamine / N,N-dimethyl-formamide / 5 h

2: N-ethyl-N,N-diisopropylamine / 36 h

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

4: sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 1 h / 110 °C / Microwave irradiation

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 0.75 h / 80 °C / Inert atmosphere

6: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 3 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; potassium acetate; sodium hydrogencarbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;