1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol

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Chemical Name:1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol
CAS No.:727723-14-0
Molecular Formula:C₂₇H₄₀O₅
Molecular Weight:444.612
Hs Code.:

Synonyms:1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol

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Chemical Property of 1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol

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Technology Process of 1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol

There total 5 articles about 1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 151-10-0
1,3-Dimethoxybenzene

: 727723-06-0
2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)acetaldehyde

: 727723-14-0
1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol

Guidance literature:: With lithium diisopropyl amide; at -78 ℃;
DOI:10.1016/j.tetlet.2004.04.142

Reference yield:

: 142037-79-4,5508-58-7
andrographolide

: 727723-14-0
1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / PPTS / benzene / Heating

2: 95 percent / TEA / CH₂Cl₂ / 20 °C

3: 80 percent / DMAP / CH₂Cl₂ / 20 °C

4: 62 percent / KMnO₃; water / tetrahydrofuran / 20 °C

5: 80 percent / LDA / -78 °C

With dmap; TEA; water; pyridinium p-toluenesulfonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/j.tetlet.2004.04.142

Reference yield:

: 727723-05-9
(E)-3-(2-((4aR,6aS,7R,10bR)-3,3,6a,10b-tetramethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)ethylidene)furan-2(3H)-one

: 727723-14-0
1-(2,6-Dimethoxy-phenyl)-2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylene-decahydro-naphtho[2,1-d][1,3]dioxin-7-yl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / KMnO₃; water / tetrahydrofuran / 20 °C

2: 80 percent / LDA / -78 °C

With water; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2004.04.142