1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose

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Chemical Name:1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose
CAS No.:1357178-69-8
Molecular Formula:C₂₂H₂₉N₃O₆
Molecular Weight:431.489
Hs Code.:

Synonyms:1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose

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Chemical Property of 1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose

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Technology Process of 1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose

There total 9 articles about 1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 6089-04-9
3-(tetrahydropyran-2'-yloxy)propyne

: 1357178-65-4
1,2-O-isopropylidene-3-C-phenyl-5-azido-α-D-ribofuranose

: 1357178-69-8
1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; at 20 ℃; for 12h;
DOI:10.1016/j.carres.2011.12.026

Reference yield:

: C₁₈H₂₄O₆

: 1357178-69-8
1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose

Guidance literature:: Multi-step reaction with 6 steps

1: phosphomolybdic acid; silica gel / acetonitrile / 3 h / 20 °C

2: sodium periodate / ethanol; water / 12 h / 20 °C

3: sodium tetrahydroborate / ethanol; water / 12 h

4: dmap / pyridine / 3.5 h / 20 °C / Cooling with ice

5: sodium azide / N,N-dimethyl-formamide / 12 h / 120 °C

6: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water / 12 h / 20 °C

With dmap; sodium tetrahydroborate; sodium periodate; phosphomolybdic acid; sodium azide; copper(ll) sulfate pentahydrate; silica gel; sodium L-ascorbate; In pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.carres.2011.12.026

Reference yield:

: 1043894-82-1
C₁₄H₁₆O₅

: 1357178-69-8
1,2-O-isopropylidene-3-C-phenyl-5-(4-(tetrahydro-2H-pyran-2-yloxymethyl)-1H-1,2,3-triazole-1-yl)-α-D-ribofuranose

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol; water / 12 h

2: dmap / pyridine / 3.5 h / 20 °C / Cooling with ice

3: sodium azide / N,N-dimethyl-formamide / 12 h / 120 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water / 12 h / 20 °C

With dmap; sodium tetrahydroborate; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2011.12.026