2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester

Base Information

Chemical Name:2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester
CAS No.:221293-18-1
Molecular Formula:C₃₀H₃₅N₃O₅
Molecular Weight:517.625
Hs Code.:

Synonyms:2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester

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Chemical Property of 2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester

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Technology Process of 2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester

There total 9 articles about 2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: C₃₀H₃₉N₃O₅

: 221293-18-1
2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; for 1.5h; Heating / reflux;

Reference yield:

: 70432-01-8
(R)-4-methyl-hexanoyl chloride

: 221293-18-1
2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

2: 1.) KN(TMS)2; 2.) 2,4,6-triisopropylbenzenesulfonyl azide; 3.) AcOH / 1.) THF, -78 deg C; 2.) -78 deg C; 3.) -78 deg C -> r.t.

3: LiOH / tetrahydrofuran; H₂O

4: H₂ / Pd/C / ethanol

5: NaOH / dioxane; H₂O

6: diethyl phosphonocyanidate, Et₃N / tetrahydrofuran / 0 °C

7: DDQ / tetrahydrofuran / 2 h / Heating

With lithium hydroxide; sodium hydroxide; diethyl cyanophosphonate; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1016/S0040-4039(98)01228-3

Reference yield:

: 221293-04-5
(2R,4R)-2-Azido-4-methyl-hexanoic acid

: 221293-18-1
2-((1R,3R)-1-tert-Butoxycarbonylamino-3-methyl-pentyl)-5-(1H-indol-3-yl)-oxazole-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol

2: NaOH / dioxane; H₂O

3: diethyl phosphonocyanidate, Et₃N / tetrahydrofuran / 0 °C

4: DDQ / tetrahydrofuran / 2 h / Heating

With sodium hydroxide; diethyl cyanophosphonate; hydrogen; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1016/S0040-4039(98)01228-3