Technology Process of (8-Chloro-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid benzyl ester
There total 9 articles about (8-Chloro-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 52.8 g / NaOMe / methanol / 2 h / Heating
2: 52.1 g / H2 / 10percent Pd/C / ethyl acetate / 25 °C / 3361.5 Torr
3: 92 percent / methanesulfonic acid (MSA) / 0.25 h / 100 °C
4: 99 percent / 70percent aq. HClO4, H2 / 10percent Pd/C / acetic acid / 4 h / 25 °C / 2327.2 Torr
5: 25.26 g / aq. KOH / methanol / 24 h / Heating
6: SOCl2 / 4 h / 60 °C
7: aq. NaN3 / acetone / 0.5 h / 0 - 20 °C
8: toluene / 1 h / 100 °C
9: 6 h / 100 °C
With
potassium hydroxide; thionyl chloride; sodium azide; perchloric acid; methanesulfonic acid; hydrogen; sodium methylate;
palladium on activated charcoal;
In
methanol; acetic acid; ethyl acetate; acetone; toluene;
DOI:10.1021/jm00159a010
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / 70percent aq. HClO4, H2 / 10percent Pd/C / acetic acid / 4 h / 25 °C / 2327.2 Torr
2: 25.26 g / aq. KOH / methanol / 24 h / Heating
3: SOCl2 / 4 h / 60 °C
4: aq. NaN3 / acetone / 0.5 h / 0 - 20 °C
5: toluene / 1 h / 100 °C
6: 6 h / 100 °C
With
potassium hydroxide; thionyl chloride; sodium azide; perchloric acid; hydrogen;
palladium on activated charcoal;
In
methanol; acetic acid; acetone; toluene;
DOI:10.1021/jm00159a010
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 52.1 g / H2 / 10percent Pd/C / ethyl acetate / 25 °C / 3361.5 Torr
2: 92 percent / methanesulfonic acid (MSA) / 0.25 h / 100 °C
3: 99 percent / 70percent aq. HClO4, H2 / 10percent Pd/C / acetic acid / 4 h / 25 °C / 2327.2 Torr
4: 25.26 g / aq. KOH / methanol / 24 h / Heating
5: SOCl2 / 4 h / 60 °C
6: aq. NaN3 / acetone / 0.5 h / 0 - 20 °C
7: toluene / 1 h / 100 °C
8: 6 h / 100 °C
With
potassium hydroxide; thionyl chloride; sodium azide; perchloric acid; methanesulfonic acid; hydrogen;
palladium on activated charcoal;
In
methanol; acetic acid; ethyl acetate; acetone; toluene;
DOI:10.1021/jm00159a010
