ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate

Base Information

• Chemical Name: ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate
• CAS No.: 1374015-66-3
• Molecular Formula: C₂₆H₃₁NO₃
• Molecular Weight: 405.537
• Mol file: 1374015-66-3.mol

Synonyms:ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate

Chemical Property of ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate

There total 2 articles about ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(chlorocarbonyl)-3-phenylpropanoate (53588-97-9) + 2-(cycloheptylidenemethyl)benzenamine (1279722-90-5) → ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate (1374015-66-3)

Guidance literature:

With dmap; In toluene; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.tet.2012.03.004

Reference yield:

2-nitrobenzyl chloride (612-23-7) → ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate (1374015-66-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere; UV-irradiation

2.1: sodium hydride / dimethyl sulfoxide / 20 °C / Inert atmosphere

3.1: iron; acetic acid / 70 °C

4.1: dmap / toluene / 0.08 h / 20 °C

With dmap; iron; sodium hydride; acetic acid; In dimethyl sulfoxide; toluene;

DOI:10.1016/j.tet.2012.03.004

Reference yield: 20.0%

ethyl 2-benzyl-3-(2-(cycloheptylidenemethyl)phenylamino)-3-oxopropanoate (1374015-66-3) → 3a'-benzyl-5',9b'-dihydro-3'H-spiro[cycloheptane-1,1'-furo[3,4-c]quinoline]-3',4'(3a'H)-dione + ethyl 3-benzyl-4-cyclohept-1-en-1-yl-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate + C26H29NO3

Guidance literature:

With manganese(III) triacetate dihydrate; acetic acid; at 80 ℃; for 0.666667h; Microwave irradiation;

DOI:10.1016/j.tet.2012.03.004

upstream raw materials:

ethyl 2-(chlorocarbonyl)-3-phenylpropanoate

2-(cycloheptylidenemethyl)benzenamine

2-nitrobenzyl chloride