Piperazine, 1-(5-methoxy-2-pyridinyl)-4-(4-nitrophenyl)-

Base Information

Chemical Name:Piperazine, 1-(5-methoxy-2-pyridinyl)-4-(4-nitrophenyl)-
CAS No.:158399-63-4
Molecular Formula:C₁₆H₁₈N₄O₃
Molecular Weight:314.344
Hs Code.:
DSSTox Substance ID:DTXSID801202550

Synonyms:SCHEMBL8931734;DTXSID801202550;Piperazine, 1-(5-methoxy-2-pyridinyl)-4-(4-nitrophenyl)-;158399-63-4

Suppliers and Price of Piperazine, 1-(5-methoxy-2-pyridinyl)-4-(4-nitrophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperazine, 1-(5-methoxy-2-pyridinyl)-4-(4-nitrophenyl)-

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:314.13789045
Heavy Atom Count:23
Complexity:387

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CN=C(C=C1)N2CCN(CC2)C3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of Piperazine, 1-(5-methoxy-2-pyridinyl)-4-(4-nitrophenyl)-

There total 2 articles about Piperazine, 1-(5-methoxy-2-pyridinyl)-4-(4-nitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 105170-27-2
2-bromo-5-methoxypyridine

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 158399-63-4
1-(5-methoxypyridin-2-yl)-4-(4-nitrophenyl)piperazine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.9b00438

Reference yield:

: 158399-62-3
1-(5-methoxypyridin-2-yl)piperazine

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 158399-63-4
1-(5-methoxypyridin-2-yl)-4-(4-nitrophenyl)piperazine

Guidance literature:: In N,N-dimethyl acetamide; potassium carbonate;

Reference yield: 93.0%

: 158399-63-4
1-(5-methoxypyridin-2-yl)-4-(4-nitrophenyl)piperazine

: 158399-64-5
4-(4-(5-methoxypyridin-2-yl)piperazin-1-yl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrazine hydrate; In ethanol; for 3.5h; Reflux;
DOI:10.1021/acsmedchemlett.9b00438