2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine

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Chemical Name:2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine
CAS No.:221148-33-0
Molecular Formula:C₂₀H₁₆FN₃O₂S₂
Molecular Weight:413.496
Hs Code.:

Synonyms:2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine

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Chemical Property of 2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine

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Technology Process of 2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine

There total 4 articles about 2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221148-32-9
2-(4-Fluoro-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid Methyl Ester

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 221148-33-0
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine

Guidance literature:: With N-Bromosuccinimide; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In methanol; 1,2-dimethoxyethane; water;

Reference yield:

: C₁₃H₉BrFN₃S

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 221148-33-0
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine

Guidance literature:: C₁₃H₉BrFN₃S; 4-methanesulphonylphenylboronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 48h; Heating / reflux;

With hydrogenchloride; In methanol; water; pH=1;

Reference yield:

: 221148-32-9
2-(4-Fluoro-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid Methyl Ester

: 221148-33-0
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; potassium carbonate / methanol / 20 h / Heating / reflux

1.2: pH 1

2.1: N-Bromosuccinimide; sodium hydrogencarbonate / methanol / 4 h / 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 48 h / Heating / reflux

3.2: pH 1

With N-Bromosuccinimide; water; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; water;