N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide
CAS No.:1303530-24-6
Molecular Formula:C₂₀H₂₆BrNO₄S
Molecular Weight:456.401
Hs Code.:

Synonyms:N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide

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Technology Process of N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide

There total 5 articles about N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1303530-17-7
2-[(2-bromo-5-methoxybenzyl)(toluene-4-sulfonyl)amino]-3-methylbutyric acid methyl ester

: 1303530-24-6
N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 90 ℃; for 14h;
DOI:10.1055/s-0030-1258406

Reference yield:

: 17360-25-7,32013-47-1,68005-71-0
N-(p-toluenesulfonyl)-L-valine

: 1303530-24-6
N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / 20 h / 90 °C

2.1: potassium carbonate / acetonitrile / 0.5 h / 25 °C / Sonication

2.2: 14 h / 25 °C / Sonication

3.1: lithium borohydride / tetrahydrofuran / 14 h / 90 °C

With lithium borohydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-0030-1258406

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1303530-24-6
N-(2-bromo-5-methoxybenzyl)-N-(1-hydroxymethyl-2-methylpropyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 25 °C

2.1: toluene-4-sulfonic acid / 20 h / 90 °C

3.1: potassium carbonate / acetonitrile / 0.5 h / 25 °C / Sonication

3.2: 14 h / 25 °C / Sonication

4.1: lithium borohydride / tetrahydrofuran / 14 h / 90 °C

With lithium borohydride; potassium carbonate; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1055/s-0030-1258406