3-(1H-benzimidazol-1-yl)-1-phenylpropan-1-one

Base Information

• Chemical Name: 3-(1H-benzimidazol-1-yl)-1-phenylpropan-1-one
• CAS No.: 3885-72-1
• Molecular Formula: C16H14 N2 O
• Molecular Weight: 250.3
• Mol file: 3885-72-1.mol

Synonyms:Propiophenone, 3-(1-benzimidazolyl)- (7CI,8CI);3-(1-Benzimidazolyl)propiophenone; NSC 529849

Chemical Property of 3-(1H-benzimidazol-1-yl)-1-phenylpropan-1-one

Chemical Property:

• Vapor Pressure: 2.75E-08mmHg at 25°C
• Boiling Point: 449.9°Cat760mmHg
• Flash Point: 225.9°C
• Density: 1.15g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1H-benzimidazol-1-yl)-1-phenylpropan-1-one

There total 6 articles about 3-(1H-benzimidazol-1-yl)-1-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzoimidazole (51-17-2,79351-71-6) + 3-morpholino-1-phenylpropan-1-one hydrochloride (1020-16-2) → 3-(1H-benzo[d]imidazol-1-yl)-1-phenylpropan-1-one (3885-72-1)

Guidance literature:

With montmorillonite K₁₀ Clay; In water; at 80 ℃; for 6h; Green chemistry;

DOI:10.3906/kim-1802-18

Reference yield: 66.0%

benzoimidazole (51-17-2,79351-71-6) + 3-chloropropiophenone (936-59-4) → 3-(1H-benzo[d]imidazol-1-yl)-1-phenylpropan-1-one (3885-72-1)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; Reflux;

DOI:10.1016/j.bmcl.2010.11.042

Reference yield: 61.0%

benzoimidazole (51-17-2,79351-71-6) + 3-(dimethylamino)propiophenone hydrochloride (879-72-1) → 3-(1H-benzo[d]imidazol-1-yl)-1-phenylpropan-1-one (3885-72-1)

Guidance literature:

In ethanol; water; for 1h; Reflux;

DOI:10.2478/s11532-012-0062-x

upstream raw materials:

benzoimidazole

3-chloropropiophenone

3-(dimethylamino)propiophenone hydrochloride

3-morpholino-1-phenylpropan-1-one hydrochloride

Downstream raw materials:

3-(1H-benzo[d]imidazol-1-yl)-1-phenylpropan-1-ol