N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide

Base Information

• Chemical Name: N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide
• CAS No.: 1352791-49-1
• Molecular Formula: C₂₀H₃₂N₂O₄S₂
• Molecular Weight: 428.617

Synonyms:N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide

Chemical Property of N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide

Chemical Property:

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Technology Process of N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide

There total 1 articles about N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C22H34N2O5S2 → N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide (1352791-49-1) + N-[(1S,2S,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide (1352791-50-4)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201100868

Reference yield: 94.0%

trifluorormethanesulfonic acid (1493-13-6) + N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide (1352791-49-1) → 2CHF3O3S*C16H24N2O2S

Guidance literature:

With methoxybenzene; In dichloromethane; at 0 ℃;

DOI:10.1002/ejoc.201100868

Reference yield: 90.0%

N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide (1352791-49-1) → 2-methyl-N-[(1S,3aS,7aR)-3-(N-methylphenylsulfonimidoyl)-3a,4,5,6,7,7a-hexahydro-1H-inden-1-yl]propane-2-sulfonamide (1352791-69-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1002/ejoc.201100868

Downstream raw materials:

N-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-(phenylsulfonyl)octahydro-1H-inden-1-yl]-2-methylpropane-2-sulfonamide

2-methyl-N-[(1S,3aS,7aR)-3-(N-methylphenylsulfonimidoyl)-3a,4,5,6,7,7a-hexahydro-1H-inden-1-yl]propane-2-sulfonamide

tert-butyl (3R)-3-[3-(benzyloxy)benzyl]-4-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-ylamino]-4-oxobutanoate

(2R)-N₄-benzyloxy-2-[3-(benzyloxy)benzyl]-N₁-[(1S,2R,3R,3aS,7aR)-2-hydroxy-3-{(S)-N-methylphenylsulfonimidoyl}octahydro-1H-inden-1-yl]succinamide

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