2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole

Base Information

Chemical Name:2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole
CAS No.:178941-16-7
Molecular Formula:C₄₆H₅₁N₃O₈
Molecular Weight:773.926
Hs Code.:

Synonyms:2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole

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Chemical Property of 2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole

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Technology Process of 2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole

There total 9 articles about 2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.5%

: 51089-83-9
benzyl 4-ethyl-3-methyl-1H-pyrrole-2-carboxylate

: 178941-24-7
(E)-3-[2,5-Bis-acetoxymethyl-4-((E)-2-ethoxycarbonyl-vinyl)-1H-pyrrol-3-yl]-acrylic acid ethyl ester

: 178941-16-7
2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole

Guidance literature:: With toluene-4-sulfonic acid; In ethanol; at 60 - 70 ℃; for 1.5h;
DOI:10.1039/P19960001235

Reference yield:

: 2199-47-5
ethyl 3,5-dimethyl-4-ethylpyrrole-2-carboxylate

: 178941-16-7
2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) SO₂Cl₂, 2.) H₂O / 1.) Et₂O, r.t., 24 h, 2.) acetone, reflux, 45 min

2: 91.5 percent / aq. KHCO₃, I₂ / ethanol / 1.) 40 deg C, 2.5 h, 2.) 90 deg C

3: 98 percent / H₂, MgO / 10percent Pd/C / ethanol; tetrahydrofuran / 40 °C

4: Na / 4 h / 100 °C / 10 Torr

5: 67.5 percent / p-TSA / ethanol / 1.5 h / 60 - 70 °C

With sulfuryl dichloride; water; hydrogen; iodine; sodium; magnesium oxide; potassium hydrogencarbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1039/P19960001235

Reference yield:

: 53365-89-2
5-Ethoxycarbonyl-3-ethyl-4-methylpyrrole-2-carboxylic acid

: 178941-16-7
2,5-Bis(5'-benzyloxycarbonyl-3'-ethyl-4'-methylpyrrol-2'-ylmethyl)-3,4-di(2-ethoxycarbonylvinyl)pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: 91.5 percent / aq. KHCO₃, I₂ / ethanol / 1.) 40 deg C, 2.5 h, 2.) 90 deg C

2: 98 percent / H₂, MgO / 10percent Pd/C / ethanol; tetrahydrofuran / 40 °C

3: Na / 4 h / 100 °C / 10 Torr

4: 67.5 percent / p-TSA / ethanol / 1.5 h / 60 - 70 °C

With hydrogen; iodine; sodium; magnesium oxide; potassium hydrogencarbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1039/P19960001235