N²-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine

Base Information

• Chemical Name: N²-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine
• CAS No.: 183284-00-6
• Molecular Formula: C₅₂H₆₅N₅O₁₄Si₂
• Molecular Weight: 1040.28

Synonyms:N²-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine

Chemical Property of N²-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine

Chemical Property:

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Technology Process of N²-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine

There total 1 articles about N²-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-N2-isobutyrylguanosine (87865-78-9) → N2-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine (183284-00-6)

Guidance literature:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; With tin(IV) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 0.166667h;

3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-N₂-isobutyrylguanosine; In 1,2-dichloro-ethane; at 0 ℃; for 16h;

DOI:10.1080/07328309708006511

Reference yield: 84.0%

N2-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine (183284-00-6) → N2-iso-butyryl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine (183284-01-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.25h;

DOI:10.1080/07328309708006511

Reference yield:

N2-iso-butyryl-9-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine (183284-00-6) → C70H74N7O16P

Guidance literature:

Multi-step reaction with 3 steps

1: TBAF / tetrahydrofuran / 0.33 h

2: pyridine / 2 h

3: 63 percent / tetrazole / CH₂Cl₂ / 4 h

With pyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-N₂-isobutyrylguanosine

Downstream raw materials:

C₄₀H₃₉N₅O₁₃

N²-iso-butyryl-9-[2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]guanine

C₆₁H₅₇N₅O₁₅

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