(S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester

Base Information

• Chemical Name: (S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester
• CAS No.: 849114-65-4
• Molecular Formula: C₁₉H₁₇NO₃
• Molecular Weight: 307.349
• Mol file: 849114-65-4.mol

Synonyms:(S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester

Chemical Property of (S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester

There total 5 articles about (S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

indole (120-72-9) + methyl 4-phenyl-2-oxo-3-butenoate (107969-78-8,6395-86-4) → (S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester (849114-65-4)

Guidance literature:

methyl 4-phenyl-2-oxo-3-butenoate; With bis[(S)-4-phenyloxazoline-2-yl]-2-(thienyl)-ethene; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at -78 ℃; Inert atmosphere;

indole; In dichloromethane; at -78 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc34803a

Reference yield: 99.0%

2-methyl-1H-indole (95-20-5) + methyl cinnamate (103-26-4,1754-62-7) → (S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester (849114-65-4)

Guidance literature:

methyl cinnamate; With nickel(II) triflate; C₄₇H₇₂N₄O₄; In dichloromethane; at 35 ℃; for 0.5h; Inert atmosphere;

2-methyl-1H-indole; In dichloromethane; at -20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c4cc10055g

Reference yield: 83.0%

indole (120-72-9) + methyl cinnamate (103-26-4,1754-62-7) → (S)-4-(1H-indol-3-yl)-2-oxo-4-phenyl-butyric acid methyl ester (849114-65-4)

Guidance literature:

methyl cinnamate; With nickel(II) triflate; C₄₇H₇₂N₄O₄; In dichloromethane; at 35 ℃; for 0.5h; Inert atmosphere;

indole; In dichloromethane; at -20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c4cc10055g

upstream raw materials:

indole

methyl 4-phenyl-2-oxo-3-butenoate

methyl cinnamate

2-methyl-1H-indole