8-chloro-1-[(4-methyl-1-piperazinyl)methyl]-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Base Information

Chemical Name:8-chloro-1-[(4-methyl-1-piperazinyl)methyl]-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS No.:40070-25-5
Molecular Formula:C₂₂H₂₃ClN₆
Molecular Weight:406.918
Hs Code.:
Mol file:40070-25-5.mol

Synonyms:8-chloro-1-(4-methyl-piperazin-1-ylmethyl)-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

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Chemical Property of 8-chloro-1-[(4-methyl-1-piperazinyl)methyl]-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

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Technology Process of 8-chloro-1-[(4-methyl-1-piperazinyl)methyl]-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

There total 5 articles about 8-chloro-1-[(4-methyl-1-piperazinyl)methyl]-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.7%

: 109-01-3
1-methyl-piperazine

: 39479-72-6
8-chloro-1-(chloromethyl)-6-phenyl-4H-s-triazolo<4,3-a><1,4>benzodiazepine

: 40070-25-5
8-chloro-1-(4-methyl-piperazin-1-ylmethyl)-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: With potassium iodide; In N,N-dimethyl-formamide; at 25 ℃; for 18h;
DOI:10.1021/jm00178a009

Reference yield: 72.0%

: 4547-02-8
7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

: 24632-44-8
4-methyl-1-piperazinylacetic acid hydrazide

: 40070-25-5
8-chloro-1-(4-methyl-piperazin-1-ylmethyl)-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: In butan-1-ol; for 4h; Heating;
DOI:10.1135/cccc19833433

Reference yield:

: Chloro-acetic acid N'-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-hydrazide

: 40070-25-5
8-chloro-1-(4-methyl-piperazin-1-ylmethyl)-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 0.33 h / Heating

2: 77.7 percent / KI / dimethylformamide / 18 h / 25 °C

With potassium iodide; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00178a009