(1R,3S,4S)-3-methoxymethyl-p-menthane

Base Information

• Chemical Name: (1R,3S,4S)-3-methoxymethyl-p-menthane
• CAS No.: 345898-37-5
• Molecular Formula: C₁₂H₂₂O₂
• Molecular Weight: 198.305
• Mol file: 345898-37-5.mol

Synonyms:(1R,3S,4S)-3-methoxymethyl-p-menthane

Chemical Property of (1R,3S,4S)-3-methoxymethyl-p-menthane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3S,4S)-3-methoxymethyl-p-menthane

There total 1 articles about (1R,3S,4S)-3-methoxymethyl-p-menthane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(+)-neoisopulegol (20549-46-6) + chloromethyl methyl ether (107-30-2) → (1R,3S,4S)-3-methoxymethyl-p-menthane (345898-37-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo0016982

Reference yield: 65.0%

(1R,3S,4S)-3-methoxymethyl-p-menthane (345898-37-5) → 2-(1-hydroxyprop-2-yl)-5-methylcyclohexan-1-ol methoxymethyl ether (345898-38-6) + (1R,3S,4S,8R)-3-methoxymethyl-p-menthan-9-ol

Guidance literature:

(1R,3S,4S)-3-methoxymethyl-p-menthane; With diborane; In tetrahydrofuran; at 20 ℃; for 4h;

With potassium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h; Further stages.;

DOI:10.1021/jo0016982

Reference yield:

(1R,3S,4S)-3-methoxymethyl-p-menthane (345898-37-5) → (1R,2S,5R)-2-[(S)-2-hydroxy-1-methylethyl]-5-methylcyclohexan-1-ol (13834-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: B₂H₆ / tetrahydrofuran / 4 h / 20 °C

1.2: 65 percent / KOH; H₂O₂ / tetrahydrofuran; H₂O / 0.5 h / 0 °C

2.1: 87.7 percent / HCl / acetone; H₂O / 4 h / 20 °C

With hydrogenchloride; diborane; In tetrahydrofuran; water; acetone;

DOI:10.1021/jo0016982

upstream raw materials:

(+)-neoisopulegol

chloromethyl methyl ether

Downstream raw materials:

2-(1-hydroxyprop-2-yl)-5-methylcyclohexan-1-ol methoxymethyl ether

(1R,2S,5R)-2-[(S)-2-hydroxy-1-methylethyl]-5-methylcyclohexan-1-ol