1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one

Base Information

• Chemical Name: 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one
• CAS No.: 1418201-42-9
• Molecular Formula: C₂₀H₁₅F₄N₃O₂
• Molecular Weight: 405.352

Synonyms:1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one

Chemical Property of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one

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Technology Process of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one

There total 7 articles about 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-(chloromethyl)-3-fluorophenyl)-1-methyl-1H-pyrazole (1392081-37-6) + 3-hydroxy-3-(trifluoromethyl)indolin-2-one (1446687-33-7,98294-08-7) → 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one (1418201-42-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 10h;

Reference yield:

4-(4-(chloromethyl)-3-fluorophenyl)-1-methyl-1H-pyrazole (1392081-37-6) + 3-hydroxy-3-trifluoromethylbenzopyrrolidin-2-one (98294-08-7) → 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one (1418201-42-9) + 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one (1418201-41-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 10h; Sealed tube; Resolution of racemate;

Reference yield:

4-bromo-2-fluorobenzyl alcohol (188582-62-9) → 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-3-hydroxy-3-(trifluoromethyl)indolin-2-one (1418201-42-9)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 0.17 h / 160 °C / Microwave irradiation

2: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h / 20 °C

3: potassium carbonate / acetonitrile / 10 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium carbonate; caesium carbonate; In tetrahydrofuran; dichloromethane; water; acetonitrile;

upstream raw materials:

4-(4-(chloromethyl)-3-fluorophenyl)-1-methyl-1H-pyrazole

3-hydroxy-3-trifluoromethylbenzopyrrolidin-2-one

4-bromo-2-fluorobenzyl alcohol

4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole

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