acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester

Base Information

• Chemical Name: acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester
• CAS No.: 350032-67-6
• Molecular Formula: C₂₇H₃₄Br₂N₂O₈S
• Molecular Weight: 706.45

Synonyms:acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester

Chemical Property of acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester

Chemical Property:

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Technology Process of acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester

There total 5 articles about acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

acetic anhydride (108-24-7) + N-[7-bromo-5S-(7-bromo-4S-hydroxy-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino)-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl]-4-methyl-benzenesulfonamide (350032-43-8) → acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester (350032-67-6)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 20 ℃;

Reference yield:

(1R,4S,5S,6R)-3-bromo-4,5-(isopropylidenedioxy)-7-(4'-methylphenylsulfonyl)-7-azabicyclo<4.1.0>hept-2-ene (163082-04-0) → acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester (350032-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NH₃; Yb(OTf)3 / CH₂Cl₂ / 0.5 h / 50 °C

1.2: 94 percent / dioxane / 3 h / 60 - 70 °C

2.1: 93 percent / pyridine / DMAP / CH₂Cl₂ / 5 h / 20 °C

With pyridine; ammonia; ytterbium(III) triflate; dmap; In dichloromethane;

DOI:10.1021/ja0205378

Reference yield:

(3aS,7aS)-4-bromo-2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole (130669-75-9) → acetic acid 7-bromo-5S-[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester (350032-67-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: mCPBA / CH₂Cl₂

2.1: NH₃; Yb(OTf)3 / CH₂Cl₂ / 0.5 h / 50 °C

2.2: 94 percent / dioxane / 3 h / 60 - 70 °C

3.1: 93 percent / pyridine / DMAP / CH₂Cl₂ / 5 h / 20 °C

With pyridine; ammonia; 3-chloro-benzenecarboperoxoic acid; ytterbium(III) triflate; dmap; In dichloromethane;

DOI:10.1021/ja0205378

upstream raw materials:

acetic anhydride

N-[7-bromo-5S-(7-bromo-4S-hydroxy-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-ylamino)-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl]-4-methyl-benzenesulfonamide

(3aS,7aS)-4-bromo-2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole

(1S,2S,5R,6R)-3-bromo-5,6-epoxy-1,2-O-isopropylidencyclohex-3-en-1,2-diol

Downstream raw materials:

acetic acid 7-bromo-5S-[[7-bromo-2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-yl]-(2,2,2-trifluoro-acetyl)-amino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4S-yl ester

acetic acid 2,2,7-trimethyl-5-[[2,2,7,7-tetramethyl-5S-(toluene-4-sulfonylamino)-hexahydro-benzo[1,2-d;3,4-d']bis[1S,3R]dioxol-4S-yl]-(2,2,2-trifluoro-acetyl)-amino]-hexahydro-benzo[1,2-d;3,4-d']bis[1S,3R]dioxol-4S-yl ester

acetic acid 5S-[[2,2-dimethyl-4S-(toluene-4-sulfonylamino)-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-5S-yl]-(2,2,2-trifluoro-acetyl)-amino]-2,2-dimethyl-3Ra,4S,5S,7a-tetrahydro-benzo[1S,3R]dioxol-4-yl ester

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