3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile

Base Information

Chemical Name:3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile
CAS No.:1383983-75-2
Molecular Formula:C₂₆H₂₈N₄O₂
Molecular Weight:428.534
Hs Code.:

Synonyms:3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile

Suppliers and Price of 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile

There total 7 articles about 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1245515-16-5
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-indene]-1'(3'H)-one

: 1383983-75-2
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 26 h / Reflux

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

3: methanol / 15 h / 60 °C / Inert atmosphere

4: ammonia / methanol / 74 °C

5: diethylamine / carbon dioxide; methanol

6: potassium carbonate / 1,4-dioxane; water / 0.33 h / 130 °C / Microwave irradiation

With hydrogenchloride; titanium(IV) tetraethanolate; ammonia; potassium carbonate; diethylamine; In 2-methyltetrahydrofuran; 1,4-dioxane; methanol; carbon dioxide; water;

Reference yield:

: 1383985-58-7
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-imine

: 1383983-75-2
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 15 h / 60 °C / Inert atmosphere

2: ammonia / methanol / 74 °C

3: diethylamine / carbon dioxide; methanol

4: potassium carbonate / 1,4-dioxane; water / 0.33 h / 130 °C / Microwave irradiation

With ammonia; potassium carbonate; diethylamine; In 1,4-dioxane; methanol; carbon dioxide; water;

Reference yield:

: 1383985-59-8
6'-bromo-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazole]-4(3H)-thione

: 1383983-75-2
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / methanol / 74 °C

2: diethylamine / carbon dioxide; methanol

3: potassium carbonate / 1,4-dioxane; water / 0.33 h / 130 °C / Microwave irradiation

With ammonia; potassium carbonate; diethylamine; In 1,4-dioxane; methanol; carbon dioxide; water;