((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea

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Chemical Name:((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea
CAS No.:187527-06-6
Molecular Formula:C₃₃H₅₃N₁₁O₆
Molecular Weight:699.854
Hs Code.:

((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea

Synonyms:((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea

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Chemical Property of ((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea

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Technology Process of ((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea

There total 12 articles about ((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 187527-06-6
((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) isobutyl chloroformate, triethylamine, 2.) NaBH₄ / 1.) THF, 0 deg C, 2.) water

2: 86 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 3 h / 25 °C

3: 74 percent / HCl / H₂O; tetrahydrofuran / 12 h / 25 °C

4: triethylamine / CH₂Cl₂ / 2 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; triethylamine; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja9631256

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 187527-06-6
((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 3 h / 25 °C

2: 84 percent / HCl / H₂O; tetrahydrofuran / 12 h / 25 °C

3: triethylamine / CH₂Cl₂ / 2 h / 0 °C

With hydrogenchloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja9631256

Reference yield:

: 82010-31-9
(S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester

: 187527-06-6
((S)-1-{3-[(S)-1-(3-{2-[3-(2-{3-[(S)-1-Aminomethyl-2-(4-hydroxy-phenyl)-ethyl]-ureido}-ethyl)-ureido]-ethyl}-ureidomethyl)-2-phenyl-ethyl]-ureidomethyl}-3-methyl-butyl)-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 3 h / 25 °C

2: 74 percent / HCl / H₂O; tetrahydrofuran / 12 h / 25 °C

3: triethylamine / CH₂Cl₂ / 2 h / 0 °C

With hydrogenchloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja9631256