Technology Process of 4-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)aniline
There total 3 articles about 4-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate;
In
1,4-dioxane; water;
at 90 ℃;
for 18h;
Overall yield = 10 g;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride; zinc / water / 4 h / Reflux
2: lithium hexamethyldisilazane / tetrahydrofuran / 22 h / -78 - 20 °C / Inert atmosphere
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 18 h / 90 °C / Inert atmosphere
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; lithium hexamethyldisilazane; zinc;
In
tetrahydrofuran; 1,4-dioxane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 22 h / -78 - 20 °C / Inert atmosphere
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 18 h / 90 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; water;
