2-methyl-7-(4-(trifluoromethyl)benzyl)-6-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-ol

Base Information

Chemical Name:2-methyl-7-(4-(trifluoromethyl)benzyl)-6-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-ol
CAS No.:1615246-46-2
Molecular Formula:C₂₃H₁₅F₆N₃O
Molecular Weight:463.382
Hs Code.:

Synonyms:2-methyl-7-(4-(trifluoromethyl)benzyl)-6-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-ol

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Chemical Property of 2-methyl-7-(4-(trifluoromethyl)benzyl)-6-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-ol

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Technology Process of 2-methyl-7-(4-(trifluoromethyl)benzyl)-6-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-ol

There total 2 articles about 2-methyl-7-(4-(trifluoromethyl)benzyl)-6-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1615246-34-8
C₃₃H₃₁F₆N₃O₅

: 1615246-46-2
2-methyl-7-(4-(trifluoromethyl)benzyl)-6-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-ol

Guidance literature:: With silver trifluoroacetate; trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol501459e

Reference yield:

: 705-31-7
4-trifluoromethylphenylacetylene

: 1615246-30-4
C₁₅H₂₂IN₃O₅

: 1615246-46-2
2-methyl-7-(4-(trifluoromethyl)benzyl)-6-(4-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tributyl-amine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.33 h / 80 °C / Inert atmosphere; Microwave irradiation

2: trifluoroacetic acid; silver trifluoroacetate / dichloromethane / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributyl-amine; silver trifluoroacetate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol501459e