Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-2-(2-methyl-1,3-benzodioxol-2-yl)ethyl)amino)ethyl)-, hydrochloride

Base Information

Chemical Name:Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-2-(2-methyl-1,3-benzodioxol-2-yl)ethyl)amino)ethyl)-, hydrochloride
CAS No.:87081-21-8
Molecular Formula:C₂₀H₂₅NO₄*ClH
Molecular Weight:379.884
Hs Code.:
DSSTox Substance ID:DTXSID801007326
Mol file:87081-21-8.mol

Synonyms:87081-21-8;Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-2-(2-methyl-1,3-benzodioxol-2-yl)ethyl)amino)ethyl)-, hydrochloride;DTXSID801007326;LS-43039;4-(1-Hydroxy-2-{[1-(2-methyl-2H-1,3-benzodioxol-2-yl)propan-2-yl]amino}propyl)phenol--hydrogen chloride (1/1);4-[1-Hydroxy-2-[1-(2-methylbenzo[1,3]dioxol-2-yl)propan-2-ylamino]prop yl]phenol hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-2-(2-methyl-1,3-benzodioxol-2-yl)ethyl)amino)ethyl)-, hydrochloride

Chemical Property:

Vapor Pressure:1.42E-11mmHg at 25°C
Boiling Point:518.5°C at 760 mmHg
Flash Point:267.4°C
PSA：70.95000
LogP:4.56280
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:379.1550360
Heavy Atom Count:26
Complexity:410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1(OC2=CC=CC=C2O1)C)NC(C)C(C3=CC=C(C=C3)O)O.Cl

Technology Process of Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-2-(2-methyl-1,3-benzodioxol-2-yl)ethyl)amino)ethyl)-, hydrochloride

There total 4 articles about Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-2-(2-methyl-1,3-benzodioxol-2-yl)ethyl)amino)ethyl)-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1-(4-Benzyloxy-phenyl)-2-[1-methyl-2-(2-methyl-benzo[1,3]dioxol-2-yl)-ethylamino]-propan-1-one; hydrochloride

: 87081-21-8
4-{1-Hydroxy-2-[1-methyl-2-(2-methyl-benzo[1,3]dioxol-2-yl)-ethylamino]-propyl}-phenol; hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; at 60 ℃; under 2280 Torr;

Reference yield:

: 65304-53-2
3-(2-methyl-1,3-benzodioxol-2-yl)-2-propanone

: 87081-21-8
4-{1-Hydroxy-2-[1-methyl-2-(2-methyl-benzo[1,3]dioxol-2-yl)-ethylamino]-propyl}-phenol; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / H₂ / 5percent Pt/C / ethanol / 40 °C / 1520 Torr

2: 86 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

3: 59 percent / 1) Et₃N, 2) HCl / ethanol / 9 h / Heating

4: 54 percent / H₂ / 5percent Pd/C / ethanol; H₂O / 60 °C / 2280 Torr

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; platinum on activated charcoal; In ethanol; water;

Reference yield:

: 87081-24-1
1-methyl-2-(2-methyl-1,3-benzodioxol-2-yl)ethylamine

: 87081-21-8
4-{1-Hydroxy-2-[1-methyl-2-(2-methyl-benzo[1,3]dioxol-2-yl)-ethylamino]-propyl}-phenol; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / 1) Et₃N, 2) HCl / ethanol / 9 h / Heating

2: 54 percent / H₂ / 5percent Pd/C / ethanol; H₂O / 60 °C / 2280 Torr

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; water;