{(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol

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Chemical Name:{(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol
CAS No.:1177419-79-2
Molecular Formula:C₂₄H₂₈N₄O₇S
Molecular Weight:516.575
Hs Code.:

Synonyms:{(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol

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Chemical Property of {(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol

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Technology Process of {(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol

There total 1 articles about {(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1177421-30-5
2-chloro-5-(methylsulfonyl)pyrazine

: 1177421-67-8
C₁₉H₂₄N₂O₅

: 1177419-79-2
{(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol

Guidance literature:: 2-chloro-5-(methylsulfonyl)pyrazine; C₁₉H₂₄N₂O₅; With potassium carbonate; In acetonitrile; at 0 - 20 ℃; for 8h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 83.0%

: 1177419-79-2
{(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol

: 1177419-80-5
(2S)-2-(3-{5-[((4R,5S)-4-(hydroxymethyl)-5-methyl-4,5-dihydro-1,3-oxazol-2-yl)]-1H-pyrrol-2-yl}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenoxy)propan-1-ol

Guidance literature:: {(4R,5S)-2-[5-(3-{[(2S)-1-methoxypropan-2-yl]oxy}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrol-2-yl]-5-methyl-4,5-dihydro-1,3-oxazol-4-yl}methanol; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With water; sodium hydroxide; In dichloromethane;