1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one

Base Information

• Chemical Name: 1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one
• CAS No.: 1260149-74-3
• Molecular Formula: C₁₅H₁₁F₃O₃S
• Molecular Weight: 328.312
• Mol file: 1260149-74-3.mol

Synonyms:1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one

Chemical Property of 1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one

There total 18 articles about 1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-((4-(trifluoromethyl)phenyl)sulfonyl)acetonitrile (186405-37-8) + phenylboronic acid (98-80-6) → 1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one (1260149-74-3)

Guidance literature:

2-((4-(trifluoromethyl)phenyl)sulfonyl)acetonitrile; phenylboronic acid; With [Rh(OH)(cod)]2; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; at 75 ℃; for 14h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; water; at 75 ℃; for 3h;

DOI:10.1021/ol102598p

Reference yield: 84.0%

acetophenone O-acetyloxime (19433-17-1) + sodium 4-trifluoromethylbenzenesulfinate → 1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one (1260149-74-3)

Guidance literature:

acetophenone O-acetyloxime; sodium 4-trifluoromethylbenzenesulfinate; With copper diacetate; In dimethyl sulfoxide; at 100 ℃; for 6h; Schlenk technique; Inert atmosphere;

With silica gel; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.201311217

Reference yield: 82.0%

phenylacetylene (536-74-3) + sodium 4-trifluoromethylbenzenesulfinate → 1-phenyl-2-((4-(trifluoromethyl)phenyl)sulfonyl)ethan-1-one (1260149-74-3)

Guidance literature:

sodium 4-trifluoromethylbenzenesulfinate; With 2-Picolinic acid; copper(l) iodide; trimethylsilylazide; In methanol; for 0.0833333h; Green chemistry;

phenylacetylene; With oxygen; In methanol; at 25 - 28 ℃; under 760.051 Torr; Irradiation; Green chemistry;

DOI:10.1039/d1gc00736j

upstream raw materials:

2-((4-(trifluoromethyl)phenyl)sulfonyl)acetonitrile

phenylboronic acid

C₉H₆F₃NS

4-trifluoromethylbenzenethiol