(R)-2-(2-(8-(hydroxymethyl)-1-isopropyl-7-(methylsulfonyl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-4-(trifluoromethyl)pyrimidin-5-yl)propan-2-ol

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Chemical Name:(R)-2-(2-(8-(hydroxymethyl)-1-isopropyl-7-(methylsulfonyl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-4-(trifluoromethyl)pyrimidin-5-yl)propan-2-ol
CAS No.:1456692-91-3
Molecular Formula:C₂₄H₂₉F₃N₄O₄S
Molecular Weight:526.58
Hs Code.:

Synonyms:(R)-2-(2-(8-(hydroxymethyl)-1-isopropyl-7-(methylsulfonyl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-4-(trifluoromethyl)pyrimidin-5-yl)propan-2-ol

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Chemical Property of (R)-2-(2-(8-(hydroxymethyl)-1-isopropyl-7-(methylsulfonyl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-4-(trifluoromethyl)pyrimidin-5-yl)propan-2-ol

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Technology Process of (R)-2-(2-(8-(hydroxymethyl)-1-isopropyl-7-(methylsulfonyl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-4-(trifluoromethyl)pyrimidin-5-yl)propan-2-ol

There total 1 articles about (R)-2-(2-(8-(hydroxymethyl)-1-isopropyl-7-(methylsulfonyl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-4-(trifluoromethyl)pyrimidin-5-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

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: 73792-06-0
ethyl-4-amino-2-fluorobenzoate

: 1456692-91-3
(R)-2-(2-(8-(hydroxymethyl)-1-isopropyl-7-(methylsulfonyl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-4-(trifluoromethyl)pyrimidin-5-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 15 steps

1.1: N,N-dimethyl-formamide / 20 h / 60 °C

2.1: Iodine monochloride; acetic acid / N,N-dimethyl-formamide / 3.67 h / 60 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: diisobutylaluminium hydride / toluene / 3 h / 0 °C

5.1: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

7.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 0.17 h / Inert atmosphere

7.2: 8 h / 65 °C

8.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

9.1: caesium carbonate / tetrahydrofuran; methanol / 4 h / 20 °C

10.1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / dichloromethane; water; toluene / 20 h / 20 °C

11.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

11.2: 0.75 h / 20 °C

12.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

13.1: N-ethyl-N,N-diisopropylamine / dichloromethane; isopropyl alcohol / 15 h / 60 °C

14.1: pyridine / dichloromethane / 10 h / 20 °C

15.1: lanthanum(III) chloride bis(lithium chloride) complex / tetrahydrofuran / 0.33 h / 20 °C

15.2: 0.5 h / 0 °C / Supercritical conditions; Resolution of racemate

With pyridine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; lanthanum(III) chloride bis(lithium chloride) complex; hydrogen; Iodine monochloride; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; caesium carbonate; Dess-Martin periodane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;