2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester

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Chemical Name:2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester
CAS No.:199658-09-8
Molecular Formula:C₂₀H₂₈O₄
Molecular Weight:332.44
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester

Chemical Property:

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Technology Process of 2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester

There total 4 articles about 2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18301-63-8
buta-2,3-dienyltrimethylsilane

: 1027169-34-1
2,2-Dimethyl-propionic acid (R)-3-benzyloxy-4-oxo-butyl ester

: 199658-09-8
2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester

: 2,2-Dimethyl-propionic acid (3R,4S)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; Yield given;
DOI:10.1016/S0040-4039(97)10077-6

Reference yield:

: 199658-08-7
2,2-Dimethyl-propionic acid (R)-3-benzyloxy-4-hydroxy-butyl ester

: 199658-09-8
2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -60 - 25 °C

2: TiCl₄ / CH₂Cl₂ / -78 °C

With oxalyl dichloride; titanium tetrachloride; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(97)10077-6

Reference yield:

: 199658-07-6
2,2-Dimethyl-propionic acid (R)-3-hydroxy-4-(4-methoxy-benzyloxy)-butyl ester

: 199658-09-8
2,2-Dimethyl-propionic acid (3R,4R)-3-benzyloxy-4-hydroxy-5-methylene-hept-6-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran

2: Et₃SiH, TMSOTf / CH₂Cl₂ / -35 °C

3: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -60 - 25 °C

4: TiCl₄ / CH₂Cl₂ / -78 °C

With triethylsilane; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; titanium tetrachloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(97)10077-6