4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-trien-6-yl)butyric acid, gadolinium complex of

Base Information

• Chemical Name: 4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-trien-6-yl)butyric acid, gadolinium complex of
• CAS No.: 910449-48-8
• Molecular Formula: C₂₅H₃₀N₅O₆*Gd
• Molecular Weight: 653.793

Synonyms:4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-trien-6-yl)butyric acid, gadolinium complex of

Chemical Property of 4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-trien-6-yl)butyric acid, gadolinium complex of

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Technology Process of 4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-trien-6-yl)butyric acid, gadolinium complex of

There total 7 articles about 4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-trien-6-yl)butyric acid, gadolinium complex of which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-6-yl)-4-(4-nitrophenyl)butyric acid, gadolinium complex of (910449-74-0) → 4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-6-yl)butyric acid, gadolinium complex of (910449-48-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In water; for 6h; under 2250.23 Torr;

Reference yield:

(9-ethoxycarbonylmethyl-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-3-yl)acetic acid, ethyl ester of (910449-71-7) → 4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-6-yl)butyric acid, gadolinium complex of (910449-48-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / di-isopropyl ether; acetonitrile / 48 h / 85 °C

2: hydrogenchloride / water / 48 h / Reflux

3: sodium hydroxide / water / 50 - 80 °C / pH 5

4: hydrogen / palladium 10% on activated carbon / water / 6 h / 2250.23 Torr

With hydrogenchloride; hydrogen; potassium carbonate; sodium hydroxide; palladium 10% on activated carbon; In di-isopropyl ether; water; acetonitrile;

Reference yield:

tert-butyl 3,9-bis(2-nitrophenylsulfonyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadecane-1(15),11,13-triene-6-carbamate (353246-05-6) → 4-(4-aminophenyl)-2-(3,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-6-yl)butyric acid, gadolinium complex of (910449-48-8)

Guidance literature:

Multi-step reaction with 7 steps

1: mercaptoacetic acid; lithium hydroxide / N,N-dimethyl-formamide / 6.5 h / 25 °C

2: potassium carbonate / di-isopropyl ether; acetonitrile / 24 h / Reflux

3: trifluoroacetic acid / 1.5 h / 25 °C

4: potassium carbonate / di-isopropyl ether; acetonitrile / 48 h / 85 °C

5: hydrogenchloride / water / 48 h / Reflux

6: sodium hydroxide / water / 50 - 80 °C / pH 5

7: hydrogen / palladium 10% on activated carbon / water / 6 h / 2250.23 Torr

With hydrogenchloride; hydrogen; potassium carbonate; mercaptoacetic acid; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; palladium 10% on activated carbon; In di-isopropyl ether; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

tert-butyl 3,9-bis(2-nitrophenylsulfonyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadecane-1⁽¹⁵⁾,11,13-triene-6-carbamate

tert-butyl 3,6,9,15-tetraazabicyclo[9.3.1]pentadecane-1⁽¹⁵⁾,11,13-triene-6-carbamate

2-(3,9-Bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-trien-6-yl)-4-(4-nitrophenyl)butyric acid

3,9-bis(ethoxycarbonylmethyl)-3,6,9,15-tetraaza-bicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-triene-6-carboxylic acid, tert-butyl ester of

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