Technology Process of 1-(2-(((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)methyl)amino)ethyl)imidazolidin-2-one
There total 7 articles about 1-(2-(((6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)methyl)amino)ethyl)imidazolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-aminoethylimidazolidone; C18H12FNO2;
In
tetrahydrofuran;
at 20 ℃;
for 14h;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 20 ℃;
for 0.333333h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere
3.1: sulfuric acid / 1,2-dimethoxyethane; water
3.2: 0.83 h / 0 - 5 °C
3.3: 0.5 h / 0 °C
4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
4.2: 18 h / 90 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere
6.1: tetrahydrofuran / 14 h / 20 °C
6.2: 0.33 h / 20 °C
With
sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere
3.1: sulfuric acid / 1,2-dimethoxyethane; water
3.2: 0.83 h / 0 - 5 °C
3.3: 0.5 h / 0 °C
4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
4.2: 18 h / 90 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere
6.1: tetrahydrofuran / 14 h / 20 °C
6.2: 0.33 h / 20 °C
With
sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;