trabectedin intermediate

Base Information

Chemical Name:trabectedin intermediate
CAS No.:236743-98-9
Molecular Formula:C₃₁H₃₇N₃O₇
Molecular Weight:563.651
Hs Code.:

Synonyms:C₃₁H₃₇N₃O₇

Suppliers and Price of trabectedin intermediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 10 raw suppliers

Chemical Property of trabectedin intermediate

Chemical Property:

Boiling Point:705.5±60.0 °C(Predicted)
PKA:14.28±0.10(Predicted)
Density:1.35±0.1 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of trabectedin intermediate

There total 15 articles about trabectedin intermediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 236743-97-8
C₄₇H₅₅N₃O₇Si

: 236743-98-9
C₃₁H₃₇N₃O₇

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 0.75h;
DOI:10.1021/ol990553i

Reference yield: 50.0%

: 236744-08-4
C₃₁H₃₈N₄O₆

: 236743-98-9
C₃₁H₃₇N₃O₇

Guidance literature:: With acetic acid; sodium nitrite; In tetrahydrofuran; water; at 0 ℃; for 3h;
DOI:10.1021/ol0062502

Reference yield:

$cyanosafracin B$: 96996-50-8
cyanosafracin B

: 236743-98-9
C₃₁H₃₇N₃O₇

Guidance literature:: Multi-step reaction with 13 steps

1: 81 percent / ethanol / 23 h / 23 °C

2: 83 percent / diisopropylethylamine; dimethylaminopyridine / acetonitrile / 6 h / 40 °C

3: 68 percent / NaOH / methanol; H₂O / 2.5 h / 20 °C

4: H₂ / Pd/C / dimethylformamide / 2 h / 23 °C

5: Cs₂CO₃ / dimethylformamide / 2 h / 100 °C

6: 56 percent / Cs₂CO₃ / dimethylformamide / 3 h / 23 °C

7: TFA / CH₂Cl₂ / 4 h / 23 °C

8: 87 percent / CH₂Cl₂ / 1 h / 23 °C

9: 82 percent / HCl / dioxane / 1 h / 23 °C

10: 98 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

11: 88 percent / diisopropylethylamine; dimethylaminopyridine / acetonitrile / 6 h / 40 °C

12: 83 percent / Zn; AcOH / H₂O / 7 h / 23 °C

13: 50 percent / NaNO₂; AcOH / tetrahydrofuran; H₂O / 3 h / 0 °C

With pyridine; hydrogenchloride; dmap; sodium hydroxide; hydrogen; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1: Acylation / 2: Substitution / 3: Hydrolysis / 4: Reduction / 5: Substitution / 6: Alkylation / 7: Elimination / 8: Addition / 9: Edman degradation / 10: Substitution / 11: Substitution / 12: Elimination / 13: Substitution;
DOI:10.1021/ol0062502