N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide

Base Information

• Chemical Name: N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide
• CAS No.: 1268691-10-6
• Molecular Formula: C₂₄H₁₈F₃N₃O
• Molecular Weight: 421.422
• Mol file: 1268691-10-6.mol

Synonyms:N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide

Chemical Property of N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide

There total 3 articles about N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyl-1-chloroisoquinoline-4-carboxamide (1268691-29-7) + 3-trifluoromethylaniline (98-16-8) → N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide (1268691-10-6)

Guidance literature:

at 150 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.bmc.2010.11.059

Reference yield:

4-bromoisoquinoline (1532-97-4) → N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide (1268691-10-6)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium tungstate monohydrate; dihydrogen peroxide; acetic acid / 3 h / 80 °C

2: trichlorophosphate / N,N-dimethyl-formamide; toluene / 20 °C / Inert atmosphere; Cooling with ice

3: tert.-butyl lithium / tetrahydrofuran; hexane / -80 °C / Inert atmosphere

4: thionyl chloride / toluene / 0.33 h / 120 °C / Microwave irradiation

5: toluene / 0.17 h / 80 °C / Microwave irradiation

6: 0.25 h / 150 °C / Microwave irradiation

With thionyl chloride; sodium tungstate monohydrate; dihydrogen peroxide; tert.-butyl lithium; acetic acid; trichlorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmc.2010.11.059

Reference yield:

1-chloroisoquinoline-4-carboxylic acid chloride → N-benzyl-1-[3-(trifluoromethyl)phenyl-amino]isoquinoline-4-carboxamide (1268691-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 0.17 h / 80 °C / Microwave irradiation

2: 0.25 h / 150 °C / Microwave irradiation

In toluene;

DOI:10.1016/j.bmc.2010.11.059

upstream raw materials:

4-bromoisoquinoline

N-benzyl-1-chloroisoquinoline-4-carboxamide

3-trifluoromethylaniline