9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

Base Information

• Chemical Name: 9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate
• CAS No.: 111649-54-8
• Molecular Formula: C₂₇H₃₆O₈S₂
• Molecular Weight: 552.71
• Mol file: 111649-54-8.mol

Synonyms:9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

Chemical Property of 9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

There total 21 articles about 9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

4-<2-(4-methanesulfonyloxybutyl)-1,3-dithian-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate (111649-53-7) → 2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 9-hydroxy-1-methyl-5-oxo-nonyl ester (111649-55-9) + 9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate (111649-54-8)

Guidance literature:

With mercury dichloride; mercury(II) oxide; In water; acetonitrile; for 1h; Heating;

DOI:10.1016/S0040-4020(01)90012-2

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate (111649-54-8)

Guidance literature:

Multi-step reaction with 12 steps

1: aq. hydrochloric acid / Ambient temperature

2: 79 percent / BF₃*OEt₂ / CHCl₃ / 7 h / Ambient temperature

3: 80 percent / toluene-p-sulfonic acid / CH₂Cl₂ / 6 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -15 deg C; 2.) THF, -15 deg C to 0 deg C

5: 81 percent / toluene-p-sulfonic acid / methanol / 0.33 h / Ambient temperature

6: 89 percent / toluene-p-sulfonic acid / methanol

7: 82 percent / sodium borohydride / methanol / 8 h / Ambient temperature

8: 59 percent / pyridine / CH₂Cl₂ / Ambient temperature

9: toluene p-sulfonic acid / methanol

10: 87 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

11: 35 percent / mercuric chloride, mercuric oxide / acetonitrile; H₂O / 1 h / Heating

12: triethyl amine

With pyridine; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; mercury dichloride; mercury(II) oxide; In methanol; dichloromethane; chloroform; water; acetonitrile;

DOI:10.1016/S0040-4020(01)90012-2

Reference yield:

5-(1',3'-dithian-2'-yl)-1-pentanol (57795-10-5) → 9-methanesulfonyloxy-1-methyl-5-oxo-nonyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate (111649-54-8)

Guidance literature:

Multi-step reaction with 10 steps

1: 80 percent / toluene-p-sulfonic acid / CH₂Cl₂ / 6 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, -15 deg C; 2.) THF, -15 deg C to 0 deg C

3: 81 percent / toluene-p-sulfonic acid / methanol / 0.33 h / Ambient temperature

4: 89 percent / toluene-p-sulfonic acid / methanol

5: 82 percent / sodium borohydride / methanol / 8 h / Ambient temperature

6: 59 percent / pyridine / CH₂Cl₂ / Ambient temperature

7: toluene p-sulfonic acid / methanol

8: 87 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

9: 35 percent / mercuric chloride, mercuric oxide / acetonitrile; H₂O / 1 h / Heating

10: triethyl amine

With pyridine; sodium tetrahydroborate; n-butyllithium; toluene-4-sulfonic acid; triethylamine; mercury dichloride; mercury(II) oxide; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4020(01)90012-2

upstream raw materials:

methanesulfonyl chloride

2,4-Dimethoxy-6-phenylsulfanylmethyl-benzoic acid 9-hydroxy-1-methyl-5-oxo-nonyl ester

4-<2-(4-methanesulfonyloxybutyl)-1,3-dithian-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

tetrahydro-2H-2-pyranol

Downstream raw materials:

4-<2-(4-iodobutyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate

4-<2-(4-methanesulfonyloxy butyl)-1,3-dioxalan-2-yl>-1-methylbutyl-2,4-dimethoxy-6-<(phenylthio) methyl> benzoate