2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine

Base Information

Chemical Name:2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine
CAS No.:104295-13-8
Molecular Formula:C₂₅H₂₈N₂O₂S
Molecular Weight:420.576
Hs Code.:

Synonyms:2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine

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Chemical Property of 2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine

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Technology Process of 2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine

There total 6 articles about 2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 27160-08-3
2-(3,4-dimethoxyphenyl)-ethylchloride

: 2095-28-5
N-methyl-2-(10H-phenothiazin-10-yl)ethan-1-amine

: 104295-13-8
2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine

Guidance literature:: N-methyl-2-(10H-phenothiazin-10-yl)ethan-1-amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

2-(3,4-dimethoxyphenyl)-ethylchloride; With triisobutylaluminum; In tetrahydrofuran; hexane; toluene; for 48h; Reflux; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.09.021

Reference yield:

: 7417-21-2
2-(3,4-dimethoxyphenyl)ethyl alcohol

: 104295-13-8
2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus pentachloride; calcium carbonate / toluene / 4.17 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 48 h / Reflux; Inert atmosphere

With n-butyllithium; phosphorus pentachloride; calcium carbonate; In tetrahydrofuran; hexane; toluene;
DOI:10.1016/j.ejmech.2017.09.021

Reference yield:

: 522-24-7
fenethazine

: 104295-13-8
2-(3,4-dimethoxyphenyl)-N-methyl-N-(2-phenothiazin-10-ylethyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,2-dichloro-ethane / 1 h / Reflux

2.1: 2 h / Reflux

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 48 h / Reflux; Inert atmosphere

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; 1,2-dichloro-ethane;
DOI:10.1016/j.ejmech.2017.09.021