3,6-dibromo-4,5-dimethyl-pyrocatechol

Base Information

• Chemical Name: 3,6-dibromo-4,5-dimethyl-pyrocatechol
• CAS No.: 3938-15-6
• Molecular Formula: C₈H₈Br₂O₂
• Molecular Weight: 295.958
• Mol file: 3938-15-6.mol

Synonyms:3,6-dibromo-4,5-dimethyl-pyrocatechol

Chemical Property of 3,6-dibromo-4,5-dimethyl-pyrocatechol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,6-dibromo-4,5-dimethyl-pyrocatechol

There total 1 articles about 3,6-dibromo-4,5-dimethyl-pyrocatechol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-dimethyl-[1,2]benzoquinone (4370-50-7) → 3,6-dibromo-4,5-dimethyl-pyrocatechol (3938-15-6)

Guidance literature:

With chloroform; bromine;

Reference yield: 86.0%

bromethyl methyl ether (13057-17-5) + 3,6-dibromo-4,5-dimethyl-pyrocatechol (3938-15-6) → C12H16Br2O4 (1129550-38-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/j.bmcl.2012.02.034

Reference yield:

3,6-dibromo-4,5-dimethyl-pyrocatechol (3938-15-6) → C33H36O7 (1370355-32-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / toluene / 9 h / 110 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / toluene / 10 h / 110 °C

4: methanol; potassium carbonate / dichloromethane / 0 °C

5: sodium hydride / N,N-dimethyl-formamide / 0 °C

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; toluene; 2: Suzuki-Miyaura coupling / 3: Suzuki-Miyaura coupling;

DOI:10.1016/j.bmcl.2012.02.034

upstream raw materials:

4,5-dimethyl-[1,2]benzoquinone

Downstream raw materials:

C₁₂H₁₆Br₂O₄

C₃₃H₃₆O₇

C₄₀H₃₉N₃O₉

C₃₉H₄₈N₆O₆S