(1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine

Base Information

Chemical Name:(1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine
CAS No.:900780-96-3
Molecular Formula:C₃₀H₃₃NO₄
Molecular Weight:471.596
Hs Code.:

Synonyms:(1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine

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Technology Process of (1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine

There total 7 articles about (1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 900780-95-2
4-[(2'S,3'S,4'R,5'R)-5'-benzoyloxymethyl-3',4'-dibenzyloxy-N-benzyloxycarbonylpyrrolidin-2'-yl]but-3-en-2-one

: 900780-96-3
(1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 3102.89 Torr;
DOI:10.1016/j.tet.2006.04.003

Reference yield:

: 872345-55-6
(2S,3S,4R,5R)-3,4-dibenzyloxy-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine

: 900780-96-3
(1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 79 percent / K₂CO₃ / acetone / 0.5 h / 20 °C

2.1: 95 percent / TEA; DMAP / CH₂Cl₂ / 20 h / 20 °C

3.1: 84 percent / TBAF*3H₂O / tetrahydrofuran / 20 °C

4.1: 4 Angstroem molecular sieves; NMO; TPAP / CH₂Cl₂ / 1 h / 20 °C

5.1: NaH / tetrahydrofuran / 1 h / 20 °C

5.2: 520 mg / tetrahydrofuran / 0.08 h / 20 °C

6.1: 74 percent / H₂ / Pd/C / methanol / 24 h / 3102.89 Torr

With dmap; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; TEA; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetone; 5.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2006.04.003

Reference yield:

: 900780-94-1
(2R,3R,4S,5R)-2-Benzoyloxymethyl-3,4-bis-benzyloxy-5-formyl-pyrrolidine-1-carboxylic acid benzyl ester

: 900780-96-3
(1S,2R,3R,5S,7aS)-3'-benzoyloxymethyl-1,2-dibenzyloxy-5-methylpyrrolizidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: 520 mg / tetrahydrofuran / 0.08 h / 20 °C

2.1: 74 percent / H₂ / Pd/C / methanol / 24 h / 3102.89 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; 1.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2006.04.003