[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate

Base Information

Chemical Name:[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate
CAS No.:909556-48-5
Molecular Formula:C₃₉H₄₅N₂O₁₀P
Molecular Weight:732.767
Hs Code.:

Synonyms:[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate

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Chemical Property of [(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate

There total 8 articles about [(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 909556-47-4
[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl [2,3,4-tri-O-benzyl-5-O-(4,4'-dimethoxytrityl)-1-D-ribityl] phosphate

: 909556-48-5
[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate

Guidance literature:: With water; acetic acid; In dichloromethane; at 23 ℃; for 4h;
DOI:10.1016/j.carres.2005.10.023

Reference yield:

: 2,3,4-tri-O-benzyl-1-O-pivaloyl-5-O-(propen-1-yl)-D-ribitol

: 909556-48-5
[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4.65 g / HgO; HgCl₂ / acetone; H₂O / 0.5 h / 23 °C

2.1: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C

3.1: 90 percent / NaOMe / dioxane; methanol / 72 h / 23 °C

4.1: 61 percent / EtN(i-Pr)2 / 1,2-dichloro-ethane / 2 h / 0 - 23 °C

5.1: tetrazole / acetonitrile / 1 h / 23 °C

5.2: 77 percent / pyridine; iodine / acetonitrile; tetrahydrofuran; H₂O

6.1: 88 percent / HOAc; water / CH₂Cl₂ / 4 h / 23 °C

With 1H-tetrazole; water; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; mercury dichloride; mercury(II) oxide; In 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone; acetonitrile;
DOI:10.1016/j.carres.2005.10.023

Reference yield:

: 909715-58-8
2,3,4-tri-O-benzyl-1-O-pivaloyl-D-ribitol

: 909556-48-5
[(N-benzyloxycarbonyl)-2-aminoethyl] 2-cyanoethyl (2,3,4-tri-O-benzyl-1-D-ribityl) phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / EtN(i-Pr)2 / acetonitrile / 1.5 h / 23 °C

2.1: 90 percent / NaOMe / dioxane; methanol / 72 h / 23 °C

3.1: 61 percent / EtN(i-Pr)2 / 1,2-dichloro-ethane / 2 h / 0 - 23 °C

4.1: tetrazole / acetonitrile / 1 h / 23 °C

4.2: 77 percent / pyridine; iodine / acetonitrile; tetrahydrofuran; H₂O

5.1: 88 percent / HOAc; water / CH₂Cl₂ / 4 h / 23 °C

With 1H-tetrazole; water; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.carres.2005.10.023