1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Base Information

Chemical Name:1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide
CAS No.:637319-29-0
Molecular Formula:C₂₆H₁₈F₄N₄O₃S
Molecular Weight:542.514
Hs Code.:

Synonyms:1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

There total 9 articles about 1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 637319-29-0
1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: N-methylmorpholine / tetrahydrofuran / 0 - 20 °C

3: 13.7 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 20 °C

4: Et₃N / CH₂Cl₂ / 5 h / 0 - 20 °C

5: 1.62 g / tetrabutylammonium bromide / toluene; H₂O / 18 h / Heating

6: 90 percent / NaClO₂; NaH₂PO₄ / H₂O; acetonitrile / 24 h / 20 °C

7: oxalyl chloride; DMF / CH₂Cl₂ / 18 h / 0 °C

8: DMAP / CHCl₃ / 18 h

With 4-methyl-morpholine; dmap; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; oxalyl dichloride; tetrabutylammomium bromide; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; chloroform; water; toluene; acetonitrile;
DOI:10.1021/jm030212h

Reference yield:

: 5326-27-2
2-hydrazino-benzoic acid

: 637319-29-0
1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: N-methylmorpholine / tetrahydrofuran / 0 - 20 °C

3: 13.7 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 20 °C

4: Et₃N / CH₂Cl₂ / 5 h / 0 - 20 °C

5: 1.62 g / tetrabutylammonium bromide / toluene; H₂O / 18 h / Heating

6: 90 percent / NaClO₂; NaH₂PO₄ / H₂O; acetonitrile / 24 h / 20 °C

7: oxalyl chloride; DMF / CH₂Cl₂ / 18 h / 0 °C

8: DMAP / CHCl₃ / 18 h

With 4-methyl-morpholine; dmap; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; oxalyl dichloride; tetrabutylammomium bromide; acetic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; chloroform; water; toluene; acetonitrile;
DOI:10.1021/jm030212h

Reference yield:

: 637318-91-3
1-(2-hydroxymethylphenyl)-3-trifluoromethyl-5-(2-furyl)-1H-pyrazole

: 637319-29-0
1-(2-cyanomethylphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 5 h / 0 - 20 °C

2: 1.62 g / tetrabutylammonium bromide / toluene; H₂O / 18 h / Heating

3: 90 percent / NaClO₂; NaH₂PO₄ / H₂O; acetonitrile / 24 h / 20 °C

4: oxalyl chloride; DMF / CH₂Cl₂ / 18 h / 0 °C

5: DMAP / CHCl₃ / 18 h

With dmap; sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; tetrabutylammomium bromide; triethylamine; N,N-dimethyl-formamide; In dichloromethane; chloroform; water; toluene; acetonitrile;
DOI:10.1021/jm030212h