Technology Process of 2-amino-5-mesityl-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
There total 4 articles about 2-amino-5-mesityl-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(2,4,6-trimethylphenyl)acetaldehyde;
With
trimethylsilyl bromide; dimethyl sulfoxide;
In
acetonitrile;
at 0 - 20 ℃;
for 0.5h;
2-amino-4-hydroxy-6-methylaminopyrimidine;
With
potassium carbonate;
In
dimethyl sulfoxide;
at 100 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine
2: trimethylsilyl bromide / dimethyl sulfoxide; acetonitrile
3: potassium carbonate / dimethyl sulfoxide
With
trimethylsilyl bromide; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
dimethyl sulfoxide; acetonitrile;
1: Swern oxidation;
DOI:10.1016/j.bmcl.2011.02.086
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trimethylsilyl bromide / dimethyl sulfoxide; acetonitrile
2: potassium carbonate / dimethyl sulfoxide
With
trimethylsilyl bromide; potassium carbonate;
In
dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmcl.2011.02.086
