ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate

Base Information

• Chemical Name: ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate
• CAS No.: 146537-41-9
• Molecular Formula: C₂₁H₂₀ClNO₂
• Molecular Weight: 353.848
• Mol file: 146537-41-9.mol

Synonyms:ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate

Chemical Property of ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate

There total 4 articles about ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

nitromethane (75-52-5) + 4-methyl-benzaldehyde (104-87-0) + ethyl acetoacetate (141-97-9) + 4-chloro-aniline (106-47-8) → ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate (146537-41-9)

Guidance literature:

With dichloro copper 4-(4-amino-5-mercapto-4H-[1,2,4]H-1,2,4 triazol-3-yl)benzamide attached Fe₃O₄ nanoparticles; In neat (no solvent); at 100 ℃; for 0.333333h; Catalytic behavior; Green chemistry;

DOI:10.1039/c9ra02325a

Reference yield: 73.0%

2-[(4-chlorophenyl)amino]-1-(4-methylphenyl)ethan-1-one (60532-54-9) + ethyl acetoacetate (141-97-9) → ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate (146537-41-9)

Guidance literature:

With p-chlorobenzenamine hydrobromide; zinc(II) chloride; In benzene; for 20h; Heating;

DOI:10.1016/0223-5234(92)90092-F

Reference yield:

4-chloro-aniline (106-47-8) → ethyl 1‐(4‐chlorophenyl)‐2‐methyl‐4‐(p‐tolyl)‐1H-pyrrole‐3‐carboxylate (146537-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / ethanol / 4 h

2: 73 percent / ZnCl₂, p-chloroaniline hydrobromide / benzene / 20 h / Heating

With p-chlorobenzenamine hydrobromide; zinc(II) chloride; In ethanol; benzene;

DOI:10.1016/0223-5234(92)90092-F

upstream raw materials:

2-[(4-chlorophenyl)amino]-1-(4-methylphenyl)ethan-1-one

ethyl acetoacetate

4-chloro-aniline

4-(bromoacetyl)toluene