(4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester

Base Information

• Chemical Name: (4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester
• CAS No.: 1284281-63-5
• Molecular Formula: C₂₀H₂₅NO₅S
• Molecular Weight: 391.488
• Mol file: 1284281-63-5.mol

Synonyms:(4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester

Chemical Property of (4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester

There total 1 articles about (4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

N-benzyloxycarbamic acid ethyl ester (5555-72-6) + (4-bromobutane-1-sulfonyl)-benzene (5755-78-2) → (4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester (1284281-63-5)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.tet.2011.01.073

Reference yield: 85.5%

(4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester (1284281-63-5) → 3-benzenesulfonyl-1-benzyloxypiperidin-2-one (1284281-78-2)

Guidance literature:

(4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; water; at -78 ℃;

DOI:10.1016/j.tet.2011.01.073

Reference yield:

(4-benzenesulfonylbutyl)-N-benzyloxycarbamic acid ethyl ester (1284281-63-5) → 1-(phenylmethoxy)-2-piperidinone (101335-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 °C

2.1: sodium amalgam; disodium hydrogenphosphate / methanol / 3 h / 0 °C

With disodium hydrogenphosphate; sodium amalgam; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;

DOI:10.1016/j.tet.2011.01.073

upstream raw materials:

N-benzyloxycarbamic acid ethyl ester

(4-bromobutane-1-sulfonyl)-benzene

Downstream raw materials:

1-(phenylmethoxy)-2-piperidinone

3-benzenesulfonyl-1-benzyloxypiperidin-2-one

3-benzenesulfonyl-1-benzyloxy-3-{2-[2-(3'-benzenesulfonyl-1'-benzyloxy-2'-oxopiperidin-3'-yl)ethoxy]ethyl}piperidin-2-one

1-benzyloxy-3-{2-[2-(1'-benzyloxy-2'-oxopiperidin-3'-yl)ethoxy]ethyl}piperidin-2-one