(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate

Base Information

Chemical Name:(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate
CAS No.:133299-32-8
Molecular Formula:C₃₆H₃₉N₅O₇S
Molecular Weight:685.801
Hs Code.:

Synonyms:(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate

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Chemical Property of (1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate

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Technology Process of (1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate

There total 5 articles about (1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 133299-31-7
(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol

: 1005-56-7
phenylcarbonochloridothioate

: 133299-32-8
(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate

Guidance literature:: With dmap; In dichloromethane; for 0.75h;
DOI:10.1039/P19910002479

Reference yield:

: 105797-60-2
2-amino-6-(2-methoxyethoxy)purine

: 133299-32-8
(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) lithium hydride / 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h

2: 90 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.75 h

With dmap; lithium hydride; In dichloromethane;
DOI:10.1039/P19910002479

Reference yield:

: 117641-39-1
(2R,3S)-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexan-3-ol

: 133299-32-8
(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentyl phenoxythiocarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH, 2) tetrabutylammonium iodide / 1) THF, r.t., 1 h, 2) DMF, reflux, 1.5 h

2: 1) lithium hydride / 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h

3: 90 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.75 h

With dmap; tetra-(n-butyl)ammonium iodide; lithium hydride; sodium hydride; In dichloromethane;
DOI:10.1039/P19910002479