Terguride

Base Information Edit

Chemical Name:Terguride
CAS No.:37686-84-3
Deprecated CAS:85649-11-2
Molecular Formula:C20H28 N4 O
Molecular Weight:340.469
Hs Code.:
European Community (EC) Number:253-624-2
UNII:21OJT43Q88
DSSTox Substance ID:DTXSID3045809
Nikkaji Number:J32.502C
Wikipedia:Terguride
Wikidata:Q7702355
NCI Thesaurus Code:C152567
Pharos Ligand ID:XNDK3YK5JZSJ
Metabolomics Workbench ID:154210
ChEMBL ID:CHEMBL73151
Mol file:37686-84-3.mol

Synonyms:dironyl;dironyl maleate (1:1);N-(D-6-methyl-8-isoergolin-1-yl)-N',N'-diethylurea;terguride;transdihydrolisuride;VUFB 6638

Suppliers and Price of Terguride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
trans-DihydroLisuride
10 mg
$ 2800.00

Crysdot
1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea 95+%
1g
$ 1186.00

American Custom Chemicals Corporation
TERGURIDE 95.00%
10MG
$ 2804.55

Alichem
1,1-Diethyl-3-((6aR,9S)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)urea
1g
$ 988.80

Total 26 raw suppliers

Chemical Property of Terguride Edit

Chemical Property:

Vapor Pressure:8.3E-14mmHg at 25°C
Melting Point:203-204° (dec); mp 205-207° (dec) (Cerny)
Refractive Index:1.6620 (estimate)
Boiling Point:588°C at 760 mmHg
PKA:13.60±0.20(Predicted)
Flash Point:309.4°C
PSA：51.37000
Density:1.21g/cm³
LogP:3.26050
Storage Temp.:2-8°C
Solubility.:DMSO: soluble
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:340.22631153
Heavy Atom Count:25
Complexity:494

Purity/Quality:

99% ^*data from raw suppliers

trans-DihydroLisuride ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 23/24/25
Safety Statements: 36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)C(=O)NC1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)C
Isomeric SMILES:CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)C
Recent EU Clinical Trials:Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial to
Description Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys.1?Partial agonist at recruitment of β-arrestin2 to the D2 receptor.2 Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.3
Uses An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent.

Technology Process of Terguride

There total 9 articles about Terguride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18016-80-3,36307-98-9,107492-84-2,107596-79-2,140387-89-9
lisuride

: 37686-84-3
terguride

Guidance literature:: With lithium amide; ammonia; lithium; aniline; In tetrahydrofuran; at -45 ℃; 1.) 30 min; 2.) 1 h;
DOI:10.1055/s-1986-31850