(+)-(S_S,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide

Base Information

• Chemical Name: (+)-(S_S,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide
• CAS No.: 885315-17-3
• Molecular Formula: C₁₂H₁₆F₃NOS
• Molecular Weight: 279.326
• Mol file: 885315-17-3.mol

Synonyms:(+)-(S_S,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide

Chemical Property of (+)-(S_S,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(S_S,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide

There total 11 articles about (+)-(S_S,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

bromobenzene (108-86-1,52753-63-6) + (SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide (1219607-83-6) → (+)-(SS,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide (885315-17-3)

Guidance literature:

bromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; optical yield given as %de;

DOI:10.1016/j.jfluchem.2009.12.023

Reference yield: 72.0%

→ (+)-(SS,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide (885315-17-3)

Guidance literature:

In toluene; at -78 ℃; for 0.25h; Glovebox; Inert atmosphere;

With potassium hexamethylsilazane; In toluene; at -78 ℃;

Reference yield: 66.0%

(S,E)-2-methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide (929642-48-8,1219607-83-6) + bromobenzene (108-86-1,52753-63-6) → (+)-(SS,S)-2-methyl-N-(2,2,2-trifluoro-1-phenylethyl)propane-2-sulfinamide (885315-17-3)

Guidance literature:

bromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(S,E)-2-methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide; In tetrahydrofuran; hexane; toluene; at -78 ℃; for 0.0833333h;

DOI:10.1021/ol063001q

upstream raw materials:

2-Methyl-propane-2-sulfinic acid ((R)-1-ethoxy-2,2,2-trifluoro-ethyl)-amide

(S,E)-2-methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide

bromobenzene

(S_S)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

Downstream raw materials:

(S)-2,2,2-trifluoro-1-phenylethan-1-amine hydrochloride