2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester

Base Information

• Chemical Name: 2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester
• CAS No.: 152610-09-8
• Molecular Formula: C₄₅H₄₁FO₆
• Molecular Weight: 696.815
• Mol file: 152610-09-8.mol

Synonyms:2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester

Chemical Property of 2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester

There total 10 articles about 2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-benzyloxy-1-(4-fluorophenyl)-5-ethyl-4-(3-chloro-1-propyloxy)benzene (152120-07-5) + 2-(2-benzyl-3-hydroxyphenoxy)benzoic acid methyl ester (152610-08-7) → 2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester (152610-09-8)

Guidance literature:

With potassium carbonate; dimethyl sulfoxide; potassium iodide; In butanone; for 18h; Heating;

DOI:10.1021/jm00022a006

Reference yield:

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone (29682-12-0) → 2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester (152610-09-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 40 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; potassium iodide; In tetrachloromethane; ethanol; dimethyl sulfoxide; butanone; benzene;

DOI:10.1021/jm00022a006

Reference yield:

2-(phenylmethyl)-1,3-dihydroxybenzene (3769-40-2) → 2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester (152610-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 7 percent / copper bronze, K₂CO₃ / pyridine / 6 h / Heating

2: 40 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

With copper; potassium carbonate; dimethyl sulfoxide; potassium iodide; In pyridine; butanone;

DOI:10.1021/jm00022a006

upstream raw materials:

2-benzyloxy-1-(4-fluorophenyl)-5-ethyl-4-(3-chloro-1-propyloxy)benzene

2-(2-benzyl-3-hydroxyphenoxy)benzoic acid methyl ester

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

2-(phenylmethyl)-1,3-dihydroxybenzene

Downstream raw materials:

2-{2-Benzyl-3-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-phenoxy}-benzoic acid methyl ester