BMS-641988

Base Information

Chemical Name:BMS-641988
CAS No.:1093276-09-5
Molecular Formula:C₂₀H₂₀F₃N₃O₅S
Molecular Weight:471.457
Hs Code.:

Synonyms:BMS-641988

Suppliers and Price of BMS-641988

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of BMS-641988

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of BMS-641988

There total 17 articles about BMS-641988 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: [3aR-(3aα,4β,5α,7β,7aα)]-4-(octahydro-5-amino-4,7-dimethyl-1,3-dioxo-4,7-epoxy-2H-isoindol-2-yl)-2-(trifluoromethyl)benzonitrile

: 594-44-5
Ethanesulfonyl chloride

: 1093276-09-5
BMS-641988

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00173

Reference yield:

: C₂₀H₂₀F₃N₃O₅S

: 1093276-09-5
BMS-641988

: N-((3aS,4S,5S,7S,7aR)-2-(4-cyano-3-(trifluoromethyl)phenyl)-4,7-dimethyl-1,3-dioxooctahydro-1H-4,7-epoxyisoindol-5-yl)ethanesulfonamide

Guidance literature:: With Chiralcel OD-H column (250 x 4.6 mm, 5 μm); In hexane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: C₂₃H₂₃F₃N₂O₇

: 1093276-09-5
BMS-641988

Guidance literature:: Multi-step reaction with 5 steps

1.1: Chiracel OD / ethanol; n-heptane / Resolution of racemate

2.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 22 °C

3.1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 1.5 h / 50 °C / Molecular sieve; Inert atmosphere

3.2: 1.5 h / 75 °C / Molecular sieve; Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 22 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; diphenyl phosphoryl azide; water; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; n-heptane; dichloromethane; 3.1: |Curtius Rearrangement;
DOI:10.1021/acsmedchemlett.5b00173