(2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide

Base Information

Chemical Name:(2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide
CAS No.:1268515-40-7
Molecular Formula:C₁₈H₁₃F₃N₄O₂
Molecular Weight:374.322
Hs Code.:

Synonyms:(2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide

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Chemical Property of (2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide

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Technology Process of (2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide

There total 3 articles about (2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 304-20-1
hydralazine hydrochloride

: 199679-35-1
3-(4-trifluoromethoxyphenyl)acrylic acid

: 1268515-40-7
(2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm101510d

Reference yield:

: (E)-methyl 3-[4-(trifluoromethoxy)phenyl]prop-2-enoate

: 1268515-40-7
(2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: water; potassium carbonate / methanol / 3 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm101510d

Reference yield:

: 659-28-9
p-trifluoromethoxybenzaldehyde

: 1268515-40-7
(2E,N',E)-3-(4-trifluoromethoxyphenyl)-N'-[phthalazin-1-(2H)-ylidiene]acrylohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

1.2: 20 h / 25 °C / Inert atmosphere

2.1: water; potassium carbonate / methanol / 3 h / Reflux

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm101510d