Technology Process of (2,4-dihydroxyphenyl)(7,8-dimethoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone
There total 8 articles about (2,4-dihydroxyphenyl)(7,8-dimethoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1.1: sodium hydride / hexane; mineral oil; tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling with ice
1.2: 16 h / Reflux
2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C
2.2: -78 - 20 °C
3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 12 h
4.1: niobium pentachloride / acetonitrile / 0 - 20 °C
With
n-butyllithium; niobium pentachloride; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; hexane; dimethyl sulfoxide; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2013.03.079
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide / 4 h / 145 °C
2.1: palladium 10% on activated carbon; triethylsilane / methanol / 0.25 h / Inert atmosphere
3.1: N-Bromosuccinimide; ammonium acetate / acetonitrile / 0.33 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C
4.2: -78 - 20 °C
5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 12 h
6.1: niobium pentachloride / acetonitrile / 0 - 20 °C
With
triethylsilane; N-Bromosuccinimide; n-butyllithium; palladium 10% on activated carbon; ammonium acetate; niobium pentachloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.03.079
