4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine

Base Information

Chemical Name:4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine
CAS No.:220953-48-0
Molecular Formula:C₂₁H₃₃BrN₆
Molecular Weight:449.437
Hs Code.:

Synonyms:4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine

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Chemical Property of 4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine

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Technology Process of 4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine

There total 7 articles about 4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 220953-42-4
4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine

: 220953-48-0
4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine

Guidance literature:: With ammonium hydroxide; sodium dithionite; In 1,4-dioxane; water; at 25 ℃;
DOI:10.1021/jm980224g

Reference yield:

: 21691-43-0
(R,S)-2-(N-benzyloxycarbonylamino)pentanoic acid

: 220953-48-0
4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / HOBt, Et₃N, DCC / tetrahydrofuran / 12 h / Ambient temperature

2: 77 percent / H₂ / 5 percent Pd/C / ethanol / 14 h / 2585.74 Torr

3: Et₃N / ethanol / 1 h / Ambient temperature

4: dimethylformamide / 60 °C

5: 62 percent / BH₃*THF / tetrahydrofuran / 14 h

6: 100 percent / Na₂S₂O₄, NH₄OH / dioxane; H₂O / 25 °C

With ammonium hydroxide; sodium dithionite; borane-THF; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980224g

Reference yield:

: 197803-18-2
N-CBz-D,L-norvaline dimethylamide

: 220953-48-0
4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methylpyrimidine-4,5-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / H₂ / 5 percent Pd/C / ethanol / 14 h / 2585.74 Torr

2: Et₃N / ethanol / 1 h / Ambient temperature

3: dimethylformamide / 60 °C

4: 62 percent / BH₃*THF / tetrahydrofuran / 14 h

5: 100 percent / Na₂S₂O₄, NH₄OH / dioxane; H₂O / 25 °C

With ammonium hydroxide; sodium dithionite; borane-THF; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980224g