3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide

Base Information

Chemical Name:3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide
CAS No.:1453088-31-7
Molecular Formula:C₂₄H₂₃N₃O₄
Molecular Weight:417.464
Hs Code.:

Synonyms:3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide

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Chemical Property of 3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide

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Technology Process of 3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide

There total 10 articles about 3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453089-45-6
4-methoxy-3-(7-{2-methoxy-5-[(R)-1-((R)-2-methyl-propane-2-sulfinylamino)ethyl]phenyl}furo[3,2-b]pyridin-2-yl)benzamide

: 1453088-31-7
3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 34841-06-0
3-bromo-4-methoxybenzylaldehyde

: 1453088-31-7
3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: titanium(IV) isopropylate / tetrahydrofuran / 1 h / 70 °C

2: dichloromethane; tetrahydrofuran; toluene / 1 h / 20 °C / Inert atmosphere

3: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4: palladium diacetate; potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 0.75 h / 160 °C / Microwave irradiation; Inert atmosphere; Sealed tube

5: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.5 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; titanium(IV) isopropylate; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium acetate; palladium diacetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; 4: |Suzuki Coupling;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1453088-31-7
3-{7-[5-((R)-1-amino-ethyl)-2-methoxy-phenyl]furo[3,2-b]pyridin-2-yl}-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 1,4-dioxane / 18 h / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C

3.1: trichlorophosphate / 2 h / 100 °C / Sealed tube

4.1: N-iodo-succinimide; potassium fluoride / acetonitrile / 2 h / 50 °C / Inert atmosphere

5.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

6.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 60 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

7.2: 2 h

8.1: palladium diacetate; potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 0.75 h / 160 °C / Microwave irradiation; Inert atmosphere; Sealed tube

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.5 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; N-iodo-succinimide; copper(l) iodide; oxalyl dichloride; water; palladium diacetate; sodium carbonate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 8.1: |Suzuki Coupling;