4-N-acetylamino-1,2-benzenediol diacetate

Base Information

• Chemical Name: 4-N-acetylamino-1,2-benzenediol diacetate
• CAS No.: 74332-02-8
• Molecular Formula: C₁₂H₁₃NO₅
• Molecular Weight: 251.239
• Mol file: 74332-02-8.mol

Synonyms:4-N-acetylamino-1,2-benzenediol diacetate

Chemical Property of 4-N-acetylamino-1,2-benzenediol diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-N-acetylamino-1,2-benzenediol diacetate

There total 8 articles about 4-N-acetylamino-1,2-benzenediol diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-acetamidophenyl acetate (6317-89-1) + acetic acid (64-19-7,77671-22-8) → 4-N-acetylamino-1,2-benzenediol diacetate (74332-02-8)

Guidance literature:

With boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene; at 20 ℃; for 0.5h; regioselective reaction;

DOI:10.1039/c0ob00749h

Reference yield:

4-nitro-1,2-benzenediol diacetate (36383-33-2) → 4-N-acetylamino-1,2-benzenediol diacetate (74332-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / 10percent palladium-carbon / ethanol / 2.5 h / 2068.6 Torr

2: 0.65 g / 21 h

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/0022-328X(95)05717-4

Reference yield:

4-amino-1,2-benzenediol (13047-04-6) → 4-N-acetylamino-1,2-benzenediol diacetate (74332-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: air / H₂O / pH 7.8

2: 1) NaBH₄ / 2) pyridine, 50 deg C, 2 h

With sodium tetrahydroborate; air; In water;

DOI:10.1021/jo01305a046

upstream raw materials:

acetic anhydride

monohydroxy para-quinone-imine

4-amino-1,2-benzenediol diacetate

4-nitro-1,2-benzenediol diacetate

Downstream raw materials:

4-acetamido-o-benzoquinone

1,2-diacetoxy-5-acetylamino-3-nitro-benzene

3-Hydroxyacetaminophen

acetic acid-(4,5-dihydroxy-2-nitroso-anilide)